The Escalade has a standard front seat center airbag, which deploys between the driver and front passenger, protecting them from injuries caused by striking each other in serious side impacts. The GX doesn’t offer front seat center airbags.
Over 200 people are killed each year when backed over by motor vehicles. The Escalade offers optional Reverse Automatic Braking that uses rear sensors to monitor for objects to the rear and automatically applies the brakes to prevent a collision. The GX doesn’t offer backup collision prevention brakes.
An active infrared night vision system optional on the Escalade Premium/Platinum/Sport helps the driver to more easily detect people, animals or other objects in front of the vehicle at night. Using an infrared camera and near-infrared lights to detect heat, the system then displays the image on a monitor in the dashboard. The GX doesn’t offer a night vision system.
Both the Escalade and the GX have standard driver and passenger frontal airbags, front side-impact airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, plastic fuel tanks, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, rearview cameras, available all wheel drive, blind spot warning systems and rear cross-path warning.
The Cadillac Escalade weighs 443 to 889 pounds more than the Lexus GX. The NHTSA advises that heavier vehicles are much safer in collisions than their significantly lighter counterparts.

